CHEMOTHERAPY-ELICITED EXOSOMAL MIR-378A-3P AND MIR-378D PROMOTE BREAST CANCER STEMNESS AND CHEMORESISTANCE VIA THE ACTIVATION OF EZH2/STAT3 SIGNALING

Abstract Background Not all breast cancer (BC) patients who receive neoadjuvant chemotherapy achieve a pathologic complete response (pCR), but the reasons for this are unknown.Previous studies have shown that exosomes produced in the tumor microenvironment in response to chemotherapy promote a chemotherapy-resistant phenotype in tumors.However, the

Abstract A long-reach robotic arm is useful for applications such as nuclear plant decommissioning, inspection, and firefighting.However, for such arms, a small external reaction force can result in large loads on proximal arm actuators because of long moment arms.This problem was previously solved by specialized arm designs that compensate externa

Abstract The wealth of properties in functional materials at the nanoscale has attracted tremendous interest over the last decades, spurring the development of ever more precise and ingenious characterization techniques.In ferroelectrics, for instance, scanning probe microscopy based techniques have been used in conjunction with advanced optical me